Pathway analysis: Data analysis and exploration of cancer transcriptome

How to analyze such analysis?? I keep wondering what is the best methodology to uncertain answer from the vast amount of high-throughput data. A lot of questions need to be answered. Finally, I've found a slide presentation that have similar things that I've wanted to figure out. It captivates my reading that those questions perhaps could help me to investigate more and answer my questions. Those questions that captured me are:

1. What regulatory relationships exist between the genes or protein in my dataset?

- Networks

2. Which biological and disease processes are most relevant to my genes of interest?

-Functional analysis

3. Which well-characterized cell signaling and metabolic pathways are most relevant to my experimental data?

-Canonical pathways

4. Which functions and pathways are regulated at different times, dose, disease state, array vs proteomic studies?

-Comparison

5. Search for genes associated with disease, cellular phenotypes. Create lists of genes to analyze.

-Search

6. Edit pathways, build molecular models by connecting genes of interest, identifying regulatory paths between genes

-My pathways

Hopefully from those questions, it would assist me to look into the insight of biological mechanisms in the cancer progressions. Now I'm trying to focus my study and see what happen next.. till then..

ORAL CANCER

Is oral cancer preventable?

Actually you can reduce your risk of getting oral cancer by adopting and practising healthy lifestyle habits.

How can I protect myself from getting oral cancer?

· Avoid the use of any kind of tobacco product (e.g. cigarettes, pipe tobacco, cigars, chewing tobacco) particularly when combined with heavy alcohol consumption.
· Avoid betel quid chewing especially with tobacco.
· Avoid heavy alcohol consumption.
· Prolonged, repeated exposure to the sun may increase the risk of cancer of the lip.
· Consume a diet with plenty of fresh fruits and vegetables that is rich in antioxidant vitamins A, C and E.
· Maintain good oral health.
· Visit your dentist at least once a year for an oral examination.

Oral cancer often starts as a tiny, unnoticed white or red spot or sore anywhere in the mouth.

Early detection of oral cancer improves the chances of successful treatment.

Do regular mouth self-examination. Take a few minutes periodically to examine your lips, gums, cheek lining and tongue, as well as the floor and roof of your mouth.

Take note of any of the following changes in your mouth:

· Colour changes such as white or red patches
· A lump, thickening, rough spot, crust or small eroded area
· A persistent painless ulcer/ sore that bleeds easily and does not heal
· Difficulty in chewing, swallowing, speaking or moving the jaw or tongue
· Changes in the voice
· A change in the way your teeth fit together
· Pain, tenderness or numbness in the mouth or lips

In addition, watch for other changes like drastic weight loss or a lump or mass in your neck.

If any of these conditions persists, contact your dentist for an examination.

SOURCE: http://ohd.moh.gov.my/modules/xt_conteudo/index.php?id=88

My first blog

Yo everyone,

This is my first time blogging myself. It is purposely to share my thoughts on scientific research area. Please feel free to comments and share your thoughts too so we can discuss and gain more knowledge together. Peace no war!

-NJA-